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An oral temperature of 100.6°F is consistent with signs of an infection because it indicates a mild fever. Fever is a common physiological response to infection as the body raises its temperature to create an environment less favorable for pathogens and to enhance the efficiency of the immune response. Elevated body temperature is one of the classic signs that an infection might be present, often resulting from the release of pyrogens in response to invading microorganisms.

In contrast, the other vital signs listed do not indicate any abnormality associated with infection. Blood pressure of 120/80 is considered within the normal range and does not hint at infection. A respiratory rate of 16 breaths per minute also falls within the normal range for adults, suggesting there is no respiratory distress or indication of infection. Lastly, a heart rate of 70 beats per minute is normal as well, not typically suggestive of an inflammatory response such as an infection. Thus, a mild fever, exemplified by an oral temperature of 100.6°F, is a key indicator of a possible infection.